Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish - MacEwan Users Only

Narnaware, Y., & Peter, R. (2001). Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish.
Metadata
TitleEffects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish
Author(s)Narnaware, Yuwaraj; Peter, Richard
Date2001
Keyword(s)appetite, brain, food intake, food deprivation, growth hormone, gene expression, goldfish, neuropeptide Y, refeeding, starvation
DescriptionIn mammals, NPY is a key factor in the regulation of feeding behavior. In the present study, the effects of refeeding for 1–3 h in 72–75-h food deprived (FD) goldfish on the levels of NPY mRNA in telencephalon-preoptic (TEL-POA), hypothalamus (HYP) and optic tectum-thalamus (OT-THAL) were examined, using Northern blot analysis. Goldfish FD for 72 h exhibited a significant increase in NPY mRNA levels in all brain regions. At 1 h after 72-h FD (73-h FD), NPY mRNA was significantly increased in TEL-POA and OT-THAL, but remained the same as 72-h FD fish in HYP. At 3 h after 72-h FD (75 h), all brain regions exhibited a significant increase in NPY mRNA levels. However, subsequent refeeding for 1–3 h rapidly and completely reversed the effects of FD in all brain regions, reaching fed levels within 1–3 h of refeeding. Serum GH levels were highest in 72-h FD fish, but decreased significantly over 1–3 h after 72-h FD; whereas, refeeding reversed the increase in serum GH levels only at 3 h after refeeding. Taken together, these results further support that NPY is a physiological brain transducer involved in the regulation of daily appetite and feeding in goldfish.
Peer ReviewedYes
Type of ItemJournal Articles
DOI10.1016/S1096-4959(01)00359-1
Publication InformationNarnaware, Y.K., & Peter, R.E. (2001a). Effect of food deprivation and refeeding on neuropeptide Y gene expression in goldfish. Comparative Biochemistry and Physiology, 129, 633-637. doi: 10.1016/S1096-4959(01)00359-1
MacEwan Users Onlyhttps://library.macewan.ca/cgi-bin/SFX/url.pl/93Y
LanguageEnglish
RightsAll Rights Reserved