Neuropeptide Y stimulates food consumption through multiple receptors in goldfish - MacEwan Users Only

Narnaware, Y., & Peter, R. (2001). Neuropeptide Y stimulates food consumption through multiple receptors in goldfish.
Metadata
TitleNeuropeptide Y stimulates food consumption through multiple receptors in goldfish
Author(s)Narnaware, Yuwaraj; Peter, Richard
Date2001
Keyword(s)brain, feeding behavior, food intake, goldfish, intracereboventricular, neuropeptide Y, Y1 and Y5 receptor subtypes
DescriptionIn this study, the acute effects of brain intracerebroventricular (icv) injections of mammalian neuropeptide Y (NPY) Y1 ([31Leu,34Pro]NPY), Y2 (NPY2–36) and Y5 ([d-32Trp]NPY) receptor subtype agonists on food intake in goldfish were examined. Icv injection of Y1 and Y5 receptor agonists in dosages of 1 and 5 ng/g exhibited dose-dependent effects on food intake; however, higher dosages of both receptor subtypes had desensitising effects on food intake, and caused a decrease in food intake in comparison to the lower dosages. At 10 and 20 ng/g, Y1 receptor agonist-treated fish exhibited feeding significantly lower than intact and saline-injected fish; fish treated with the same dosages of Y5 agonist exhibited food intake similar to intact and saline-injected fish. Y2 agonist had no effects on food intake. Co-icv administration of Y1 and Y5 agonists in dosages of 1 and 5 ng/g caused enhanced food intake that was additive of the individual doses alone. However, desensitising one receptor did not influence the responsiveness of the other. Co-icv injection of Y1 receptor agonist in desensitizing high dosages (10 and 15 ng/g) with Y5 receptor agonist in lower doses (1 and 5 ng/g, respectively) or vice versa, resulted in a food intake similar to the dosages of Y1 and Y5 receptor agonists at 1 and 5 ng/g given alone. Overall, this study demonstrates that NPY acts centrally through Y1 and Y5 receptors to stimulate food intake in goldfish. The Y1 and Y5 receptors appear to act independently in the stimulation of food intake in goldfish.
Peer ReviewedYes
Type of ItemJournal Articles
DOI10.1016/S0031-9384(01)00556-X
Publication InformationNarnaware, Y. K., & Peter R. E. (2001b). Neuropeptide Y (NPY) stimulates food consumption through multiple receptors in goldfish. Physiology and Behavior, 74, 185-190. doi: 10.1016/S0031-9384(01)00556-X
MacEwan Users Onlyhttps://library.macewan.ca/cgi-bin/SFX/url.pl/940
LanguageEnglish
RightsAll Rights Reserved