Parameter estimation and prediction for time-dependent concentration response curves for cytotoxicity assessment

  • Title: Parameter estimation and prediction for time-dependent concentration response curves for cytotoxicity assessment
    Author: Anton, Cristina
    Year: 2016
    Keyword(s): toxicology, linear kinetics, logistic equation, in-vitro experiments
    Description: We propose a model based on the logistic equation and linear kinetics to study the effect of toxicants with various initial concentrations on a cells' population. To efficiently estimate the model's parameters, we design an Expectation Maximization algorithm. The model is validated by showing that it accurately represents the information provided by in-vitro experiments.
    Notes: Presented on July 14 & 15, 2016 at the "International Biometric Conference" held at the Victoria Convention Centre in Victoria, B.C.
    Peer Reviewed: Yes
    Type of Item: Conference Materials
    Language: English

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