Browsing by Author "Galef Jr, Bennett"
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Item Effects of ethanol consumption by adult female rats on subsequent consumption by adolescents(2004) Honey, P. Lynne; Varley, Kevin; Galef Jr, BennettWe used a two-bottle choice test to measure voluntary ethanol consumption by adolescent rats that had lived with ethanol-consuming or water-consuming adult conspecifics. We found that housing weanlings with either a virgin or a lactating adult female rat that ingested ethanol increased the weanlings' subsequent voluntary intake of ethanol when they were fluid-deprived and provided with choices between 8% ethanol solution and water for 2 h/day. Rats housed with both an ethanol-consuming virgin female and their water-consuming dam drank more ethanol than did rats housed with a dam and virgin female, both consuming water. Rats housed with an ethanol-consuming dam and ethanol consuming adult virgin did not drink more ethanol than did rats housed with an ethanol-consuming dam and a water-consuming virgin female. In sum: (1) young rats learned socially to consume ethanol. (2) Exposure to ethanol in mother's milk was not necessary for such social learning to occur, and (3) living with an ethanol-consuming unfamiliar, virgin female conspecific resulted in enhanced ethanol intake by adolescent rats, even if a water-consuming dam was also present.Item Ethanol consumption by rat dams during gestation, lactation and weaning increases ethanol consumption by their adolescent young(2003) Honey, P. Lynne; Galef Jr, BennettIn two experiments, we examined effects of ethanol consumption in rat dams during gestation, lactation, and weaning on voluntary ethanol consumption by their adolescent young. We found that exposure to an ethanol-ingesting dam throughout gestation, lactation, and weaning enhanced voluntary ethanol consumption by 26- to 33-day-old adolescents. We systematically examined effects on adolescent ethanol intake or requiring dams to drink ethanol during various periods in their pups' development. We found that exposure to an ethanol-consuming dam during weaning enhanced adolescent ethanol consumption and exposure to a dam drinking ethanol during either gestation or while nursing enhanced adolescents' ethanol consumption only if pups also had access to ethanol during the weaning period.Item Long lasting effects of rearing by an ethanol-consuming dam on voluntary ethanol consumption by rats(2004) Honey, P. Lynne; Galef Jr, BennettFor exposure to alcohol early in life to potentiate alcohol abuse in adolescence or adulthood, consequences of early exposure to alcohol must be of considerable duration. In two experiments using Norway rats as subjects, we examined effects of exposure during weaning to a dam consuming ethanol on adolescents' later affinity for ethanol. In a preliminary experiment, we offered rat pups a choice between 8% ethanol and water for 7 days immediately after they were weaned at 26 days of age. Pups whose dam had ingested 8% ethanol for 6 days either immediately or 1 week before we weaned them drank more ethanol than pups whose dam drank only water during the same period. Independent groups of rats reared by a dam consuming 8% ethanol from postnatal days 18 to 26 and tested 1, 2, 4 or 6 weeks later all drank significantly more 8% ethanol at testing than did pups whose dam drank only water. Our data also provided confirmation of previous reports of an experience-independent greater affinity for ethanol in younger rats.