Browsing by Author "Loh, Erica"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish(2023) Johnson, Andrea; Loh, Erica; Slessor, Jordan; Verbitsky, Ryan; Franczak, Brian C.; Schalomon, Melike; Hamilton, TrevorThis study assessed the sensitivity of four anxiety-like behaviour paradigms in zebrafish: the novel tank dive test, shoaling test, light/dark test, and the less common shoal with novel object test. A second goal was to measure the extent to which the main effect measures are related to locomotor behaviours to determine whether swimming velocity and freezing (immobility) are indicative of anxiety-like behaviour. Using the well-established anxiolytic, chlordiazepoxide, we found the novel tank dive to be most sensitive followed by the shoaling test. The light/dark test and shoaling plus novel object test were the least sensitive. A principal component analysis and a correlational analysis also showed the locomotor variables, velocity and immobility, did not predict the anxiety-like behaviours across all behaviour tests.