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Browsing by Author "Marsh, Rebeccah"

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    A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model
    (2013) Rezania, Vahid; Marsh, Rebeccah; Coombe, Dennis; Tuszynski, Jack A.
    We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not.
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    A physiologically-based flow network model for hepatic drug elimination II: variable lattice lobule models
    (2013) Rezania, Vahid; Marsh, Rebeccah; Coombe, Dennis; Tuszynski, Jack A.
    We extend a physiologically-based lattice model for the transport and metabolism of drugs in the liver lobule (liver functional unit) to consider structural and spatial variability. We compare predicted drug concentration levels observed exiting the lobule with their detailed distribution inside the lobule, and indicate the role that structural variation has on these results. Liver zonation and its role on drug metabolism represent another aspect of structural inhomogeneity that we consider here. Since various liver diseases can be thought to produce such structural variations, our analysis gives insight into the role of disease on liver function and performance. These conclusions are based on the dominant role of convection in well-vascularized tissue with a given structure.