Parameter estimation and prediction for time-dependent concentration response curves for cytotoxicity assessment

Author
Anton, Cristina
Faculty Advisor
Date
2016
Keywords
toxicology , linear kinetics , logistic equation , in-vitro experiments
Abstract (summary)
We propose a model based on the logistic equation and linear kinetics to study the effect of toxicants with various initial concentrations on a cells' population. To efficiently estimate the model's parameters, we design an Expectation Maximization algorithm. The model is validated by showing that it accurately represents the information provided by in-vitro experiments.
Publication Information
DOI
Notes
Presented on July 14 & 15, 2016 at the "International Biometric Conference" held at the Victoria Convention Centre in Victoria, B.C.
Item Type
Presentation
Language
English
Rights
All Rights Reserved