Parameter estimation and prediction for time-dependent concentration response curves for cytotoxicity assessment
toxicology, linear kinetics, logistic equation, in-vitro experiments
We propose a model based on the logistic equation and linear kinetics to study the effect of toxicants with various initial concentrations on a cells' population. To efficiently estimate the model's parameters, we design an Expectation Maximization algorithm. The model is validated by showing that it accurately represents the information provided by in-vitro experiments.
Presented on July 14 & 15, 2016 at the "International Biometric Conference" held at the Victoria Convention Centre in Victoria, B.C.
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