A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes

Author
Hinow, Peter
Rezania, Vahid
Tuszynski, Jack A.
Faculty Advisor
Date
2009
Keywords
microtubules
Abstract (summary)
Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo referred to as dynamic instability. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in the polymerization of microtubules from tubulin dimers. Our model is an extension of various mathematical models developed earlier formulated in order to capture and unify the various aspects of tubulin polymerization. While attempting to use a minimal number of adjustable parameters, the proposed model covers a broad range of behaviors and has predictive features discussed in the paper. We have analyzed the range of resultant dynamical behavior of the microtubules by changing each of the parameter values at a time and observing the emergence of various dynamical regimes, that agree well with the previously reported experimental data. observing the emergence of various dynamical regimes, that agree well with reported experimental behavior.
Publication Information
Hinow, P., Rezania, V., & Tuszynski, J. (2009). Continuous model for microtubule dynamics with catastrophe, rescue, and nucleation processes. Physical Review E, 80(3), 031904. doi: 10.1103/PhysRevE.80.031904
Notes
Item Type
Article
Language
English
Rights
All Rights Reserved