On the classical vibrational coherence of carbonyl groups in the selectivity filter backbone of the KcsA ion channel

Author
Salari, Vahid
Sajadi, Maryam
Bassereh, Hassan
Rezania, Vahid
Alaei, Mojtaba
Tuszynski, Jack
Faculty Advisor
Date
2015
Keywords
KcsA ion channel , selectivity filter , carbonyl groups , vibrational frequency , degree of coherence , Pearson correlation
Abstract (summary)
It has been suggested that quantum coherence in the selectivity filter of ion channel may play a key role in fast conduction and selectivity of ions. However, it has not been clearly elucidated yet why classical coherence is not sufficient for this purpose. In this paper, we investigate the classical vibrational coherence between carbonyl groups oscillations in the selectivity filter of KcsA ion channels based on the data obtained from molecular dynamics simulations. Our results show that classical coherence plays no effective role in fast ionic conduction.
Publication Information
Salari, V., Sajadi, M., Bassereh, H., Rezania, V., Alaei, M., & Tuszynski, J. A. (2015). On the classical vibrational coherence of carbonyl groups in the selectivity filter backbone of the KcsA ion channel. Journal of Integrative Neuroscience, 14(2), 195-206. doi:10.1142/S0219635215500132
DOI
Notes
Item Type
Language
English
Rights
All Rights Reserved