Pancreatic ductal cell heterogeneity: insights into the potential for β-cell regeneration in diabetes
Faculty Advisor
Date
2025
Keywords
diabetes, pancreatic ductal heterogeneity, stem/progenitor cells, stem cell differentiation, β-cell regeneration, pancreatic endocrine cell differentiation
Abstract (summary)
Diabetes mellitus is a significant and fast-growing health problem worldwide. Cost, donor shortages, and immune rejection limit current treatment strategies. While considerable progress has been made in creating β-cells in vitro with remarkable morphological and functional resemblance to those in primary pancreatic islets, exploring alternative sources for β-cell replacement is crucial. With adult pancreatic stem cells still not conclusively identified, researchers focus their attention on heterogeneity within pancreatic ductal epithelial cells, exploring these cells as a potential source of progenitor cells for pancreatic regeneration and β-cell formation. Recent studies using techniques such as fluorescence-activated cell sorting, immunostaining and single cell RNA-sequencing have identified ductal cell heterogeneity with several subpopulations of ductal cells with progenitor-like properties and their capacity for differentiation into insulin producing cells. Here, we have reviewed the most recent studies on pancreatic ductal cell subpopulations that offer insights into potential stem-cell populations to form β-cells in diabetes treatment.
Publication Information
Britt, M., Abdilmasih, N., & Rezanejad, H. (2025). Pancreatic ductal cell heterogeneity: Insights into the potential for β-cell regeneration in diabetes. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-025-10859-y
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Embargoed Until:
2026-03-10