On the classical vibrational coherence of carbonyl groups in the selectivity filter backbone of the KcsA ion channel

Salari, VahidSajadi, MaryamBassereh, HassanRezania, VahidAlaei, MojtabaTuszynski, Jack A.2015-12-102022-05-272022-05-272015Salari, V., Sajadi, M., Bassereh, H., Rezania, V., Alaei, M., & Tuszynski, J. A. (2015). On the classical vibrational coherence of carbonyl groups in the selectivity filter backbone of the KcsA ion channel. Journal of Integrative Neuroscience, 14(2), 195-206. doi:10.1142/S0219635215500132https://hdl.handle.net/20.500.14078/443It has been suggested that quantum coherence in the selectivity filter of ion channel may play a key role in fast conduction and selectivity of ions. However, it has not been clearly elucidated yet why classical coherence is not sufficient for this purpose. In this paper, we investigate the classical vibrational coherence between carbonyl groups oscillations in the selectivity filter of KcsA ion channels based on the data obtained from molecular dynamics simulations. Our results show that classical coherence plays no effective role in fast ionic conduction.3.49 MBPDFenAll Rights ReservedKcsA ion channelselectivity filtercarbonyl groupsvibrational frequencydegree of coherencePearson correlationOn the classical vibrational coherence of carbonyl groups in the selectivity filter backbone of the KcsA ion channelArticle Post-Printhttps://doi.org/10.1142/S0219635215500132