Ye, MengshaJiang, MingdiCheng, JingLi, XuanyingLiu, ZiweiZhang, WeiyingMugo, SamuelJaffrezic-Renault, NicoleGuo, Zhenzhong2021-07-132022-05-312022-05-312020M. Ye, M. Jiang, J. Cheng, X. Li; Z. Liu, W. Zhang, S.M. Mugo, N. Jaffrezic-Renault ; Z. Guo. Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum. Sensors and Actuators B: Chemical. 2020, 308, 127692. DOI: 10.1016/j.snb.2020.127692https://hdl.handle.net/20.500.14078/2405This study presents a novel electrochemical sensor for detection of Tau-441, an Alzheimer's disease (AD) biomarker protein. The sensor comprised a glassy carbon electrode modified by chemically exfoliated single-layer reduced graphene oxide (rGO) grafted with anti-Tau antibody. Using square wave voltammetry (SWV), the electrochemical sensor yielded a linear response to Tau-441 in the 0.08 pM-80 pM concentration range, with a low detection limit of 75 fM. The sensor has been successfully tested in the detection of Tau-441 of human serum from participants with and without AD, therefore it is shown to be an efficient and effective tool for the early diagnosis of AD.enAll Rights ReservedAlzheimer's diseaseTau-441electrochemical antibody sensorsingle layer reduced graphene oxide (rGO)1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt(PTSA)Articlehttps://doi.org/10.1016/j.snb.2020.127692