Enantioselective total synthesis of (R)-(−)-complanine

Kamanos, Krystal A. D.Withey, Jonathan M.2014-10-022022-05-272022-05-272012Kamanos, K. A. D. & Withey, J. M. (2012). Enantioselective total synthesis of (R)-(−)-complanine. Beilstein Journal of Organic Chemistry, 8, 1695–1699. doi:10.3762/bjoc.8.192https://hdl.handle.net/20.500.14078/159A route is described for the enantioselective synthesis of (R)-(−)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.225.73 kbPDFenAttribution (CC BY)complanineenantioselective synthesismarine firewormnitrosoaldolorganocatalysisEnantioselective total synthesis of (R)-(−)-complanineArticlehttps://doi.org/10.3762/bjoc.8.192