The effects of mutations on the first two hours of an immune response in Drosophila larvae
The innate immune system in Drosophila melanogaster has two responses to an infection, a cellular and a humoral response. They communicate with each other to produce a functional immune system. Certain mutations in the immune system of Drosophila show an activated immune response without bacterial infection. It is not known whether this will prime the immune system and give the animal an advantage or if these mutations will cause a non-functional immune response. In my research I used a septic injury assay to test some of these mutations to determine if these mutants have an advantage in the immune response or if the immune response is non-functional. I found that these mutations caused a priming effect and decreased the response time for the immune system of Drosophila to clear an infection. This research helped us to confirm that the functionality of the immune system in these mutants have a different response than the wildtype immune response.
Presented at the Undergraduate Research in Science Conference of Alberta (URSCA).
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