Sodium methyl carbonate as an effective C1 synthon. Synthesis of carboxylic acids, benzophenones, and unsymmetrical ketones

Hurst, T. E., Deichert, J. A., Kapeniak, L., Lee, R., Harris, J., Jessop, P. G., & Snieckus, V. (2019). Sodium methyl carbonate as an effective C1 synthon. Synthesis of carboxylic acids, benzophenones, and unsymmetrical ketones. doi:https://doi.org/10.1021/acs.orglett.9b00773
Title

Sodium methyl carbonate as an effective C1 synthon. Synthesis of carboxylic acids, benzophenones, and unsymmetrical ketones

Author(s) or Creator(s)
Hurst, Timothy E.
Deichert, Julie A.
Kapeniak, Lucas
Lee, Roland
Harris, Jesse
Jessop, Philip G.
Snieckus, Victor
Date

2019

Peer Reviewed?

Yes

Keywords

sodium methyl carbonate
synthesis of symmetrical ketones
unsymmetrical ketones
Grignard reagents
organolithium
C1 synthon
alkyl metal carbonates
carboxylic acids
benzophenones

Description

Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential reactivity of sodium methyl carbonate with Grignard and organolithium reagents.

Publication Information

Timothy E. Hurst, Julie A. Deichert, Lucas Kapeniak, Roland Lee, Jesse Harris, Philip G. Jessop and Victor Snieckus. Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones, Organic letters, (2019) 21, 11, 3882-3885

DOI

https://doi.org/10.1021/acs.orglett.9b00773

Type of Item

Journal Articles

Language

English

MacEwan Users Only

https://library.macewan.ca/full-record/edswsc/000471212100002

Rights

All Rights Reserved