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Modeling the effects of drug binding on the dynamic instability of microtubules

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dc.contributor.authorHinow, Peter
dc.contributor.authorRezania, Vahid
dc.contributor.authorLopus, Manu
dc.contributor.authorJordan, Mary Ann
dc.contributor.authorTuszynski, Jack A.
dc.date.accessioned2014-10-15
dc.date.accessioned2022-05-27T01:13:19Z
dc.date.available2022-05-27T01:13:19Z
dc.date.issued2011
dc.description.abstractWe propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin in the possible presence of a microtubule associated drug. As an example for the latter, we both experimentally and theoretically study the perturbation of microtubule dynamic instability by S-methyl-D-DM1, a synthetic derivative of the microtubule-targeted agent maytansine and a potential anticancer agent. Our model predicts that among drugs that act locally at the microtubule tip, primary inhibition of the loss of GDP tubulin results in stronger damping of microtubule dynamics than inhibition of GTP tubulin addition. On the other hand, drugs whose action occurs in the interior of the microtubule need to be present in much higher concentrations to have visible effects.
dc.format.extent1.52 mb
dc.format.mimetypePDF
dc.identifier.citationHinow, P., Rezania, V., Lopus, M., Jordan, M. A., & Tuszyński, J. A. (2011). Modeling the effects of drug binding on the dynamic instability of microtubules. Physical Biology 8(5), 1–22. doi:10.1088/1478-3975/8/5/056004
dc.identifier.doihttps://doi.org/10.1088/1478-3975/8/5/056004
dc.identifier.urihttps://hdl.handle.net/20.500.14078/179
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectmicrotubules
dc.subjectdynamic instability
dc.subjectstochastic modeling
dc.titleModeling the effects of drug binding on the dynamic instability of microtubulesen
dc.typeArticle
dspace.entity.type

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