Influence of diet composition on food intake and neuropeptide Y (NPY) gene expression in goldfish brain

Author
Narnaware, Yuwaraj
Peter, Richard
Faculty Advisor
Date
2002
Keywords
appetite , feeding behavior , food preference , carbohydrate , fat , hypothalamus
Abstract (summary)
In this study, goldfish demonstrate preference for high carbohydrate and high fat diets, with no preference shown for high protein diets. Fish fed high (45% and 55%) carbohydrate (CHO) diets for 1 and 4 weeks exhibited decreased NPY gene expression in telencephalon–preoptic area (TEL–POA) and optic tectum–thalamus (OT–THAL) compared to fish fed low CHO (35% and 40%) diets. In hypothalamus (HYP), NPY gene expression was significantly increased after 1 week in fish fed both low and high CHO diets compared to control diet (40% CHO); after 4 weeks, the pattern in HYP was reversed. Fish fed a high fat (9%) diet had low NPY gene expression in TEL–POA after 1 and 4 weeks; however, HYP NPY expression was increased in fish fed a low (3%) fat diet after 1 week, and 2% and 3% fat diets after 4 weeks. In OT–THAL, NPY gene expression was decreased in fish fed a 2% fat diet for 1 week, and increased after 4 weeks. Feeding diets with different protein contents for 1 or 4 weeks did not influence NPY gene expression in goldfish brain. The results demonstrate, for the first time in a lower vertebrate, that NPY gene expression in goldfish brain is influenced by macronutrient intake.
Publication Information
Narnaware Y. K., & Peter. R. E. (2002). Influence of diet composition on food intake and hypothalamic neuropeptide Y (NPY) gene expression in goldfish. Regulatory Peptides, 103, 75-83. doi: 10.1016/S0167-0115(01)00342-1
Notes
Item Type
Article
Language
English
Rights
All Rights Reserved