Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish
| dc.contributor.author | Johnson, Andrea | |
| dc.contributor.author | Loh, Erica | |
| dc.contributor.author | Slessor, Jordan | |
| dc.contributor.author | Verbitsky, Ryan | |
| dc.contributor.author | Franczak, Brian C. | |
| dc.contributor.author | Schalomon, Melike | |
| dc.contributor.author | Hamilton, Trevor | |
| dc.date.accessioned | 2023-06-15T19:27:14Z | |
| dc.date.available | 2023-06-15T19:27:14Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | This study assessed the sensitivity of four anxiety-like behaviour paradigms in zebrafish: the novel tank dive test, shoaling test, light/dark test, and the less common shoal with novel object test. A second goal was to measure the extent to which the main effect measures are related to locomotor behaviours to determine whether swimming velocity and freezing (immobility) are indicative of anxiety-like behaviour. Using the well-established anxiolytic, chlordiazepoxide, we found the novel tank dive to be most sensitive followed by the shoaling test. The light/dark test and shoaling plus novel object test were the least sensitive. A principal component analysis and a correlational analysis also showed the locomotor variables, velocity and immobility, did not predict the anxiety-like behaviours across all behaviour tests. | |
| dc.identifier.citation | Johnson, A., Loh, E., Verbitsky, R. et al. Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish. Sci Rep 13, 3768 (2023). https://doi.org/10.1038/s41598-023-29668-9 | |
| dc.identifier.doi | https://doi.org/10.1038/s41598-023-29668-9 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14078/3136 | |
| dc.language.iso | en | |
| dc.rights | Attribution (CC BY) | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | zebrafish | |
| dc.subject | behavioral neuroscience | |
| dc.subject | anxiety | |
| dc.title | Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish | en |
| dc.type | Article |
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