Sodium methyl carbonate as an effective C1 synthon. Synthesis of carboxylic acids, benzophenones, and unsymmetrical ketones

Hurst, Timothy E.; Deichert, Julie A.; Kapeniak, Lucas; Lee, Roland; Harris, Jesse; Jessop, Philip G.; Snieckus, Victor

Sodium methyl carbonate as an effective C1 synthon. Synthesis of carboxylic acids, benzophenones, and unsymmetrical ketones

Author

Date

2019

Keywords

sodium methyl carbonate, synthesis of symmetrical ketones, unsymmetrical ketones, Grignard reagents, organolithium, C1 synthon, alkyl metal carbonates, carboxylic acids, benzophenones

Abstract (summary)

Reported is the synthesis of carboxylic acids, symmetrical ketones, and unsymmetrical ketones with selectivity achieved by exploiting the differential reactivity of sodium methyl carbonate with Grignard and organolithium reagents.

Publication Information

Timothy E. Hurst, Julie A. Deichert, Lucas Kapeniak, Roland Lee, Jesse Harris, Philip G. Jessop and Victor Snieckus. Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones, Organic letters, (2019) 21, 11, 3882-3885