Enantioselective total synthesis of (R)-(−)-complanine
complanine, enantioselective synthesis, marine fireworm, nitrosoaldol, organocatalysis
A route is described for the enantioselective synthesis of (R)-(−)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.
Kamanos, K. A. D. & Withey, J. M. (2012). Enantioselective total synthesis of (R)-(−)-complanine. Beilstein Journal of Organic Chemistry, 8, 1695–1699. doi:10.3762/bjoc.8.192
Attribution (CC BY)