Enantioselective total synthesis of (R)-(−)-complanine

Author
Kamanos, Krystal A. D.
Withey, Jonathan
Faculty Advisor
Date
2012
Keywords
complanine , enantioselective synthesis , marine fireworm , nitrosoaldol , organocatalysis
Abstract (summary)
A route is described for the enantioselective synthesis of (R)-(−)-complanine, a marine natural product isolated from Eurythoe complanata, and known to be a causative agent in inflammation. An organocatalytic, asymmetric oxyamination of a homoconjugated all-Z-dienal intermediate provides versatile and efficient access to the natural product.
Publication Information
Kamanos, K. A. D. & Withey, J. M. (2012). Enantioselective total synthesis of (R)-(−)-complanine. Beilstein Journal of Organic Chemistry, 8, 1695–1699. doi:10.3762/bjoc.8.192
DOI
Notes
Item Type
Article
Language
English
Rights
Attribution (CC BY)