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Establishing zebrafish as a model to study the anxiolytic effects of scopolamine

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dc.contributor.authorHamilton, Trevor
dc.contributor.authorMorrill, Adam
dc.contributor.authorLucas, Kayla
dc.contributor.authorGallup, Joshua
dc.contributor.authorHarris, Megan
dc.contributor.authorHealey, Meghan
dc.contributor.authorPitman, Taylor
dc.contributor.authorSchalomon, Melike
dc.contributor.authorDigweed, Shannon
dc.contributor.authorTresguerres, Martin
dc.date.accessioned2020-07-29
dc.date.accessioned2022-05-31T01:15:07Z
dc.date.available2022-05-31T01:15:07Z
dc.date.issued2017
dc.description.abstractScopolamine (hyoscine) is a muscarinic acetylcholine receptor antagonist that has traditionally been used to treat motion sickness in humans. However, studies investigating depressed and bipolar populations have found that scopolamine is also effective at reducing depression and anxiety symptoms. The potential anxiety-reducing (anxiolytic) effects of scopolamine could have great clinical implications for humans; however, rats and mice administered scopolamine showed increased anxiety in standard behavioural tests. This is in direct contrast to findings in humans, and complicates studies to elucidate the specific mechanisms of scopolamine action. The aim of this study was to assess the suitability of zebrafish as a model system to test anxiety-like compounds using scopolamine. Similar to humans, scopolamine acted as an anxiolytic in individual behavioural tests (novel approach test and novel tank diving test). The anxiolytic effect of scopolamine was dose dependent and biphasic, reaching maximum effect at 800 µM. Scopolamine (800 µM) also had an anxiolytic effect in a group behavioural test, as it significantly decreased their tendency to shoal. These results establish zebrafish as a model organism for studying the anxiolytic effects of scopolamine, its mechanisms of action and side effects.
dc.format.extent1.41MB
dc.format.mimetypePDF
dc.identifier.citationHamilton, T.J, Morrill, A., Lucas, K., Gallup, J., Harris, M., Healey, M., Pitman, T., Schalomon, M., Digweed, S.M., Tresguerres,M. 2017. Establishing zebrafish as a model to study the anxiolytic effects of scopolamine. Scientific Reports, 7(1), 15081. doi:https://doi.org/10.1038/s41598-017-15374-w
dc.identifier.doihttps://doi.org/10.1038/s41598-017-15374-w
dc.identifier.urihttps://hdl.handle.net/20.500.14078/1657
dc.languageEnglish
dc.language.isoen
dc.rightsAttribution (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectscopolamine
dc.subjectanxiety
dc.subjectzebrafish
dc.titleEstablishing zebrafish as a model to study the anxiolytic effects of scopolamineen
dc.typeReport

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