Model of ionic currents through microtubule nanopores and the lumen

Author
Freedman, Holly
Rezania, Vahid
Priel, Avner
Carpenter, Eric
Noskov, Sergei Y.
Tuszynski, Jack A.
Faculty Advisor
Date
2010
Keywords
microtubules , nanopores
Abstract (summary)
It has been suggested that microtubules and other cytoskeletal filaments may act as electrical transmission lines. An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its walls. This model is used to study how ionic conductance along the lumen is affected by flux through the nanopores when an external potential is applied across its two ends. Based on the results of Brownian dynamics simulations, the nanopores were found to have asymmetric inner and outer conductances, manifested as nonlinear IV curves. Our simulations indicate that a combination of this asymmetry and an internal voltage source arising from the motion of the C-terminal tails causes a net current to be pumped across the microtubule wall and propagate down the microtubule through the lumen. This effect is demonstrated to enhance and add directly to the longitudinal current through the lumen resulting from an external voltage source, and could be significant in amplifying low-intensity endogenous currents within the cellular environment or as a nano-bioelectronic device.
Publication Information
Freedman, H., Rezania, V., Priel, A., Carpenter, E., Noskov, S., & Tuszynski, J. (2010). Model of ionic currents through microtubule nanopores and the lumen. Physical Review E, 81(5), 051912. doi 10.1103/PhysRevE.81.051912
DOI
Notes
Item Type
Article
Language
English
Rights
All Rights Reserved