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Model of ionic currents through microtubule nanopores and the lumen

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dc.contributor.authorFreedman, Holly
dc.contributor.authorRezania, Vahid
dc.contributor.authorPriel, Avner
dc.contributor.authorCarpenter, Eric
dc.contributor.authorNoskov, Sergei Y.
dc.contributor.authorTuszynski, Jack A.
dc.date.accessioned2014-10-06
dc.date.accessioned2022-05-27T01:13:15Z
dc.date.available2022-05-27T01:13:15Z
dc.date.issued2010
dc.description.abstractIt has been suggested that microtubules and other cytoskeletal filaments may act as electrical transmission lines. An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its walls. This model is used to study how ionic conductance along the lumen is affected by flux through the nanopores when an external potential is applied across its two ends. Based on the results of Brownian dynamics simulations, the nanopores were found to have asymmetric inner and outer conductances, manifested as nonlinear IV curves. Our simulations indicate that a combination of this asymmetry and an internal voltage source arising from the motion of the C-terminal tails causes a net current to be pumped across the microtubule wall and propagate down the microtubule through the lumen. This effect is demonstrated to enhance and add directly to the longitudinal current through the lumen resulting from an external voltage source, and could be significant in amplifying low-intensity endogenous currents within the cellular environment or as a nano-bioelectronic device.
dc.format.extent849.88 kb
dc.format.mimetypePDF
dc.identifier.citationFreedman, H., Rezania, V., Priel, A., Carpenter, E., Noskov, S., & Tuszynski, J. (2010). Model of ionic currents through microtubule nanopores and the lumen. Physical Review E, 81(5), 051912. doi 10.1103/PhysRevE.81.051912
dc.identifier.doihttps://doi.org/10.1103/PhysRevE.81.051912
dc.identifier.urihttps://hdl.handle.net/20.500.14078/161
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectmicrotubules
dc.subjectnanopores
dc.titleModel of ionic currents through microtubule nanopores and the lumenen
dc.typeArticle
dspace.entity.type

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