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Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients

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dc.contributor.authorCespedes Feliciano, Elizabeth M.
dc.contributor.authorPopuri, Karteek
dc.contributor.authorCobzas, Dana
dc.contributor.authorBaracos, Vickie E.
dc.contributor.authorBeg, Mirza Faisal
dc.contributor.authorKhan, Arafat Dad
dc.contributor.authorMa, Cydney
dc.contributor.authorChow, Vincent
dc.contributor.authorChow, Vincent
dc.contributor.authorPrado, Carla M.
dc.contributor.authorXiao, Jingjie
dc.contributor.authorLiu, Vincent
dc.contributor.authorChen, Wendy Y.
dc.contributor.authorMeyerhardt, Jeffrey
dc.contributor.authorAlbers, Kathleen B.
dc.contributor.authorCaan, Bette J.
dc.date.accessioned2021-05-20
dc.date.accessioned2022-05-31T01:43:39Z
dc.date.available2022-05-31T01:43:39Z
dc.date.issued2020
dc.description.abstractBackground Body composition from computed tomography (CT) scans is associated with cancer outcomes including surgical complications, chemotoxicity, and survival. Most studies manually segment CT scans, but Automatic Body composition Analyser using Computed tomography image Segmentation (ABACS) software automatically segments muscle and adipose tissues to speed analysis. Here, we externally evaluate ABACS in an independent dataset. Methods Among patients with non‐metastatic colorectal (n = 3102) and breast (n = 2888) cancer diagnosed from 2005 to 2013 at Kaiser Permanente, expert raters annotated tissue areas at the third lumbar vertebra (L3). To compare ABACS segmentation results to manual analysis, we quantified the proportion of pixel‐level image overlap using Jaccard scores and agreement between methods using intra‐class correlation coefficients for continuous tissue areas. We examined performance overall and among subgroups defined by patient and imaging characteristics. To compare the strength of the mortality associations obtained from ABACS's segmentations to manual analysis, we computed Cox proportional hazards ratios (HRs) and 95% confidence intervals (95% CI) by tertile of tissue area. Results Mean ± SD age was 63 ± 11 years for colorectal cancer patients and 56 ± 12 for breast cancer patients. There was strong agreement between manual and automatic segmentations overall and within subgroups of age, sex, body mass index, and cancer stage: average Jaccard scores and intra‐class correlation coefficients exceeded 90% for all tissues. ABACS underestimated muscle and visceral and subcutaneous adipose tissue areas by 1–2% versus manual analysis: mean differences were small at −2.35, −1.97 and −2.38 cm2, respectively. ABACS's performance was lowest for the <2% of patients who were underweight or had anatomic abnormalities. ABACS and manual analysis produced similar associations with mortality; comparing the lowest to highest tertile of skeletal muscle from ABACS versus manual analysis, the HRs were 1.23 (95% CI: 1.00–1.52) versus 1.38 (95% CI: 1.11–1.70) for colorectal cancer patients and 1.30 (95% CI: 1.01–1.66) versus 1.29 (95% CI: 1.00–1.65) for breast cancer patients. Conclusions In the first study to externally evaluate a commercially available software to assess body composition, automated segmentation of muscle and adipose tissues using ABACS was similar to manual analysis and associated with mortality after non‐metastatic cancer. Automated methods will accelerate body composition research and, eventually, facilitate integration of body composition measures into clinical care.
dc.format.extent21.74MB
dc.format.mimetypePDF
dc.identifier.citationCespedes Feliciano E.M., Popuri K., Cobzas D., et al. , Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients, Journal of Cachexia, Sarcopenia and Muscle, April 2020. https://doi.org/10.1002/jcsm.12573
dc.identifier.doihttps://doi.org/10.1002/jcsm.12573
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2283
dc.languageEnglish
dc.language.isoen
dc.rightsAttribution-NonCommercial-NoDerivs (CC BY-NC-ND)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectbody composition
dc.subjectautomation
dc.subjectsoftware
dc.subjectadiposity
dc.subjectmuscle
dc.subjectsarcopenia
dc.subjectobesity
dc.subjectcancer
dc.titleEvaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patientsen
dc.typeArticle

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