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Effects of the avermectin, MK-243, on ovary development and salivary gland degeneration in the ixodid tick, Amblyomma hebraeum

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dc.contributor.authorFriesen, Kevin
dc.contributor.authorSuri, Reena
dc.contributor.authorKaufman, Reuben
dc.date.accessioned2016-05-09
dc.date.accessioned2022-05-28T00:38:19Z
dc.date.available2022-05-28T00:38:19Z
dc.date.issued2003
dc.description.abstractInjection of the avermectin analogue, MK-243, into engorged female Amblyomma hebraeum Koch resulted in reduced ovary weight, oocyte length, and ovary vitellin content. There was no significant reduction in hemolymph vitellogenin concentration in MK-243 treated ticks. Although MK-243 was previously shown to markedly reduce hemolymph 20E-concentration, injection of 20E, the vitellogenic hormone in this tick, did not reverse the effects of MK-243 on ovary development. These data suggest that MK-243 may exert its inhibition of egg development more at the level of vitellogenin uptake than vitellogenin synthesis. MK-243 also reversed salivary gland degeneration slightly, probably via its inhibitory effect on 20E-synthesis.
dc.description.urihttps://library.macewan.ca/cgi-bin/SFX/url.pl/8FO
dc.identifier.citationFriesen, K. J., Suri, R., & Kaufman, W. R. (2003). Effects of the avermectin, MK-243, on ovary development and salivary gland degeneration in the ixodid tick, Amblyomma hebraeum. Pesticide Biochemistry and Physiology, 76(3), 82-90. doi:10.1016/S0048-3575(03)00070-1
dc.identifier.doihttps://doi.org/10.1016/S0048-3575(03)00070-1
dc.identifier.urihttps://hdl.handle.net/20.500.14078/1017
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectavermectin
dc.subjectvitellogenesis
dc.subject20-Hydroxyecdysone
dc.subjectamblyomma hebraeum
dc.subjectMK-243
dc.subjectticks
dc.titleEffects of the avermectin, MK-243, on ovary development and salivary gland degeneration in the ixodid tick, Amblyomma hebraeumen
dc.typeArticle

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