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Vision of conspecifics decreases the effectiveness of ethanol on zebrafish behaviour

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dc.contributor.authorDean, Rachel
dc.contributor.authorHurst Radke, Nicole
dc.contributor.authorVelupillai, Nirudika
dc.contributor.authorFranczak, Brian C.
dc.contributor.authorHamilton, Trevor
dc.date.accessioned2021-12-20
dc.date.accessioned2022-05-31T01:44:53Z
dc.date.available2022-05-31T01:44:53Z
dc.date.issued2021
dc.description.abstractAquatic organisms in pharmacology and toxicology research are often exposed to compounds in isolation prior to physiological or behavioural testing. Recent evidence suggests that the presence of conspecifics during a stressful event can modulate behavioural outcomes (called ‘social buffering’) when testing occurs within the same context. It is unknown, however, whether the social environment during exposure interacts with the efficacy of anxiety-altering substances when subsequently tested in the absence of conspecifics. In this study, zebrafish were individually exposed to habitat water or ethanol (1.0% vol/vol) while untreated conspecifics were visually present or absent during dosing. Using the novel object approach test, a validated test of boldness and anxiety-like behaviour, we observed significantly greater effects of ethanol in isolated fish, compared to fish with a view of conspecifics during dosing. These results were not explained by altered locomotion during exposure, which might otherwise increase drug uptake. This highlights the need to consider the social environment during exposure when conducting and interpreting behavioural research involving drug or toxicant exposure.
dc.format.extent1.85MB
dc.format.mimetypePDF
dc.identifier.citationDean R., Hurst-Radke N., Velupillai N., Franczak B.C., and Hamilton T.J. (2021). Vision of conspecifics decreases the effectiveness of ethanol on zebrafish behaviour. PeerJ, 9:e10566. https://doi.org/10.7717/peerj.10566
dc.identifier.doihttps://doi.org/10.7717/peerj.10566
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2514
dc.languageEnglish
dc.language.isoen
dc.rightsAttribution (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectsocial buffering
dc.subjectbehavioural mimicry
dc.subjectethanol
dc.subjectzebrafish
dc.subjectnovel object approach test
dc.subjectboldness
dc.subjectanxiety-like behaviour
dc.titleVision of conspecifics decreases the effectiveness of ethanol on zebrafish behaviouren
dc.typeArticle

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