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Shoaling behaviour is differentially altered by ethanol and dopamine D1 receptor modulators in tropical marine forage fish

dc.contributor.authorHamilton, Trevor
dc.contributor.authorKline, David I.
dc.contributor.authorTresguerres, Martin
dc.date.accessioned2020-10-14
dc.date.accessioned2022-05-31T01:15:44Z
dc.date.available2022-05-31T01:15:44Z
dc.date.issued2018
dc.description.abstractAnchovies are filter-feeding fish that inhabit nearshore environments worldwide. With increasing human pharmaceutical use, drugs that alter neurological functioning are becoming more prevalent in aquatic ecosystems via wastewater effluent, creating the need for tests that can reliably determine sublethal effects of these drugs on coastal fish populations. In this study, we used Caribbean anchovies (Anchoa spp.) as a tropical marine fish model to test drug-induced alterations of locomotion and shoaling behaviour with a video-based analysis system. Consistent with its anxiolytic effects in zebrafish (Danio rerio), ethanol decreased shoal cohesion in anchovies. We also characterized the effects of drugs known to modulate the dopaminergic system in zebrafish and rodents. A D1 receptor agonist (SKF 38393) and a D1 receptor antagonist (SCH 23390) increased the time anchovy spent in the center of the arena, but neither drug had an impact on shoal cohesion. Finally, the D1 receptor agonist caused significantly lower meandering compared with fish treated with the D1 receptor antagonist and ethanol. This study suggests that anchovy is a suitable Caribbean marine model for toxicology studies.
dc.description.urihttps://library.macewan.ca/full-record/a9h/130314882
dc.identifier.citationHamilton TJ, Kline DI, Tresguerres M. Shoaling behaviour is differentially altered by ethanol and dopamine D1 receptor modulators in tropical marine forage fish. (2018). Canadian Journal of Fisheries and Aquatic Sciences. 75(7): 999-1004. doi.org/10.1139/cjfas-2018-0084
dc.identifier.doihttps://doi.org/10.1139/cjfas-2018-0084
dc.identifier.urihttps://hdl.handle.net/20.500.14078/1885
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectanchovies
dc.subjectwastewater effluent
dc.subjectdrugs
dc.subjectzebrafish
dc.subjectdopaminergic system
dc.subjectlocomotion and shoaling behaviour
dc.subjecttoxicology studies
dc.subjectD1 receptor modulators
dc.subjectethanol
dc.subjectdopamine
dc.titleShoaling behaviour is differentially altered by ethanol and dopamine D1 receptor modulators in tropical marine forage fishen
dc.typeArticle

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