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Effect of older maternal age on the risk of spontaneous preterm labor: a population-based study

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dc.contributor.authorMcIntyre, Safina
dc.contributor.authorNewburn-Cook, Christine V.
dc.contributor.authorO’Brien, Beverley
dc.contributor.authorDemianczuk, Nestor N.
dc.date.accessioned2021-06-16
dc.date.accessioned2022-05-31T01:43:55Z
dc.date.available2022-05-31T01:43:55Z
dc.date.issued2009
dc.description.abstractTo determine if older maternal age (35 years and older) at first birth was an independent risk factor for spontaneous preterm labor, we conducted a retrospective population-based cohort study. Using provincial perinatal data, we developed separate risk models for low- and high-risk women using multivariate logistic regression. We found that older maternal age exerted a direct and independent effect on spontaneous preterm labor for both nulliparous women with no preexisting chronic illnesses or pregnancy complications (low-risk) and nulliparous women who did not have any preexisting chronic illnesses, but developed one or more pregnancy complications (high-risk). Over the past several decades, the proportion of women delaying the birth of their first child until 35 years and older has increased significantly in developed countries, both in North America and Europe. In the United States, for example, births to nulliparous women 35 to 39 years of age and women 40 to 44 years increased by 36% and 70%, respectively (Cnattingius & Stephannson, 2002; Heffner, 2004). With increasing numbers of women postponing childbearing until their later reproductive years, there is increased awareness and concern among women and health care providers about the impact of advanced maternal age on maternal morbidity, the increased risk of obstetric interventions, and adverse pregnancy outcomes, including preterm birth. The results of studies on the relation between increased maternal age and preterm birth have led to inconsistent conclusions. One limitation was the failure by most researchers to investigate the heterogeneity of preterm birth. Therefore, we conducted a retrospective population-based cohort study to determine if older maternal age (35 years and older) at first birth was an independent risk factor for spontaneous preterm labor. To our knowledge this was the first such study designed specifically to examine if older maternal age acts directly or indirectly on the risk of spontaneous preterm labor. Realizing that not all women of older maternal age are a homogeneous group, we developed separate risk models for low- and high-risk women. We found that older maternal age exerted a direct and independent effect on spontaneous preterm labor for both nulliparous women with no preexistisng illnesses or pregnancy complications (low-risk) and nulliparous women who did not have any preexisting chronic illnesses but developed one or more pregnancy complications (high-risk). It is important to identify risk factors for preterm birth that are amenable to change; resulting interventions possibly could have long-lasting and far-reaching effects.
dc.description.urihttps://library.macewan.ca/full-record/rzh/105381479
dc.identifier.citationHassan McIntyre, S., Newburn-Cook, C. V., O'Brien, B., & Demianczuk, N. (2009). Effect of older maternal age on the risk of spontaneous preterm labour: A population-based study. Health Care for Women International, 30, 670-689. DOI: 10.1080/07399330802596473
dc.identifier.doihttps://doi.org/10.1080/07399330802596473
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2338
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectwomen
dc.subjectolder maternal age
dc.subjectfirst birth
dc.subjectnulliparous women
dc.subjectpregnancy complications
dc.subjectperinatal data
dc.subjectrisk models
dc.subjectspontaneous preterm labor
dc.subjectrisk factor
dc.subjectcohort study
dc.titleEffect of older maternal age on the risk of spontaneous preterm labor: a population-based studyen
dc.typeArticle

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