Repository logo
 

Liver bioreactor design issues of fluid flow and zonation, fibrosis, and mechanics: a computational perspective

Simple item page
dc.contributor.authorRezania, Vahid
dc.contributor.authorCoombe, Dennis
dc.contributor.authorTuszynski, Jack A.
dc.date.accessioned2021-06-18
dc.date.accessioned2022-05-31T01:44:00Z
dc.date.available2022-05-31T01:44:00Z
dc.date.issued2020
dc.description.abstractTissue engineering, with the goal of repairing or replacing damaged tissue and organs, has continued to make dramatic science-based advances since its origins in the late 1980’s and early 1990’s. Such advances are always multi-disciplinary in nature, from basic biology and chemistry through physics and mathematics to various engineering and computer fields. This review will focus its attention on two topics critical for tissue engineering liver development: (a) fluid flow, zonation, and drug screening, and (b) biomechanics, tissue stiffness, and fibrosis, all within the context of 3D structures. First, a general overview of various bioreactor designs developed to investigate fluid transport and tissue biomechanics is given. This includes a mention of computational fluid dynamic methods used to optimize and validate these designs. Thereafter, the perspective provided by computer simulations of flow, reactive transport, and biomechanics responses at the scale of the liver lobule and liver tissue is outlined, in addition to how bioreactor-measured properties can be utilized in these models. Here, the fundamental issues of tortuosity and upscaling are highlighted, as well as the role of disease and fibrosis in these issues. Some idealized simulations of the effects of fibrosis on lobule drug transport and mechanics responses are provided to further illustrate these concepts. This review concludes with an outline of some practical applications of tissue engineering advances and how efficient computational upscaling techniques, such as dual continuum modeling, might be used to quantify the transition of bioreactor results to the full liver scale.
dc.format.extent10.82MB
dc.format.mimetypePDF
dc.identifier.citationRezania, V., Coombe, D., & Tuszynski, J. (2020). Liver bioreactor design issues of fluid flow and zonation, fibrosis, and mechanics: A computational perspective, Journal of Functional Biomaterials, 11(1), 13. https://doi.org/10.3390/jfb11010013
dc.identifier.doihttps://doi.org/10.3390/jfb11010013
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2354
dc.languageEnglish
dc.language.isoen
dc.rightsAttribution (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectvirtual liver
dc.subjectmulti-scale modeling
dc.subjectlobule
dc.subjecttissue engineering
dc.subjectzonation
dc.subjectfibrosis
dc.subjectupscaling
dc.subjectdrug transport
dc.subjectdual continuum modeling
dc.titleLiver bioreactor design issues of fluid flow and zonation, fibrosis, and mechanics: a computational perspectiveen
dc.typeArticle
dspace.entity.type

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Liver_bioreactor_design_issues_of_fluid_flow-_2020_roam.pdf
Size:
10.82 MB
Format:
Adobe Portable Document Format
Download

Collections

Department of Physical Sciences