Computational analysis of upscaled fibrotic liver multi-lobule flows and metabolism

dc.contributor.author	Coombe, Dennis
dc.contributor.author	Wallace, Cooper
dc.contributor.author	Rezania, Vahid
dc.contributor.author	Tuszynski, Jack A.
dc.date.accessioned	2025-06-06T22:29:00Z
dc.date.available	2025-06-06T22:29:00Z
dc.date.issued	2024
dc.description.abstract	The modeling of fibrotic effects on fluid flow and metabolism in the liver can be computationally challenging. This paper combines innovative concepts based on fundamental physics to address such issues at the level of the liver functional unit, the lobule, and upscales and extends this to a multi-lobule tissue scale analysis. Fibrosis effects on fluid flow and metabolism are introduced using percolation theory and its consequences are explored for single lobule and multi-lobule patterns, without and with distortion.
dc.identifier.citation	Coombe, D., Wallace, C., Rezania, V., & Tuszynski, J. A. (2024). Computational analysis of upscaled fibrotic liver multi-lobule flows and metabolism. Processes, 12(9), 1789. https://doi.org/10.3390/pr12091789
dc.identifier.doi	https://doi.org/10.3390/pr12091789
dc.identifier.uri	https://hdl.handle.net/20.500.14078/3961
dc.language.iso	en
dc.rights	Attribution (CC BY)
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	liver
dc.subject	metabolic processes
dc.subject	computational modeling
dc.subject	fibrosis
dc.subject	lobule
dc.subject	fluid flows
dc.title	Computational analysis of upscaled fibrotic liver multi-lobule flows and metabolism	en
dc.type	Article

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