Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

Author
Stephen G. Davies
David Díez
Mohamed M. El Hammouni
A. Christopher Garner
Narciso M. Garrido
Marcus J. C. Long
Rachel M. Morrison
Andrew D. Smith
Miles J. Sweet
Withey, Jonathan
Faculty Advisor
Date
2003
Keywords
kinetic resolution , chemistry
Abstract (summary)
Comparison of the kinetic and parallel kinetic resolutions of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate allows for the efficient synthesis of both (1R,2S,5S)- and (1S,2R,5R)-enantiomers of methyl 2-amino-5-tert-butyl-cyclopentane-1-carboxylate.
Publication Information
Davies, S. G., Díez, D., El Hammouni, M. M., Garner, A. C., Garrido, N. M., Long, M. C., & ... Withey, J. M. (2003). Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate. Chemical Communications, 19, 2410-2411. Retrieved from http://pubs.rsc.org
DOI
Notes
Item Type
Article
Language
English
Rights
All Rights Reserved