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The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y2 and not Y5 receptors

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dc.contributor.authorEl Bahh, Bouchaïb
dc.contributor.authorBalosso, Silvia
dc.contributor.authorHamilton, Trevor
dc.contributor.authorHerzog, Herbert
dc.contributor.authorBeck-Sickinger, Annette
dc.contributor.authorSperk, Günther
dc.contributor.authorGehlert, Donald
dc.contributor.authorVezzani, Annamaria
dc.date.accessioned2022-05-27T01:14:59Z
dc.date.available2022-05-27T01:14:59Z
dc.date.issued2005
dc.description.abstractNeuropeptide Y (NPY) potently inhibits glutamate release and seizure activity in rodent hippocampus in vitro and in vivo, but the nature of the receptor(s) mediating this action is controversial. In hippocampal slices from rats and several wild-type mice, a Y2-preferring agonist mimicked, and the Y2-specific antagonist BIIE0246 blocked, the NPY-mediated inhibition both of glutamatergic transmission and of epileptiform discharges in two different slice models of temporal lobe epilepsy, stimulus train-induced bursting (STIB) and 0-Mg2+ bursting. Whereas Y5 receptor-preferring agonists had small but significant effects in vitro, they were blocked by BIIE0246, and a Y5 receptor-specific antagonist did not affect responses to any agonist tested in any preparation. In slices from inline image mice, NPY was without effect on evoked potentials or in either of the two slice seizure models. In vivo, intrahippocampal injections of Y2- or Y5-preferring agonists inhibited seizures caused by intrahippocampal kainate, but again the Y5 agonist effects were insensitive to a Y5 antagonist. Neither Y2- nor Y5-preferring agonists affected kainate seizures in inline image mice. A Y5-specific antagonist did not displace the binding of two different NPY ligands in WT or inline image mice, whereas all NPY binding was eliminated in the inline image mouse. Thus, we show that Y2 receptors alone mediate all the anti-excitatory actions of NPY seen in the hippocampus, whereas our findings do not support a role for Y5 receptors either in vitro or in vivo. The results suggest that agonists targeting the Y2 receptor may be useful anticonvulsants.
dc.description.urihttps://library.macewan.ca/cgi-bin/SFX/url.pl/87C
dc.identifier.citationEl Bahh, B., Balosso, S., Hamilton, T., Herzog, H., Beck-Sickinger, A.G., Sperk, G., Gehlert, D.R., Vezzani, A. and Colmers, W.F. (2005), The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y2 and not Y5 receptors. European Journal of Neuroscience, 22: 1417-1430. doi: 10.1111/j.1460-9568.2005.04338.x
dc.identifier.doihttps://doi.org/10.1111/j.1460-9568.2005.04338.x
dc.identifier.urihttps://hdl.handle.net/20.500.14078/494
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectBIIE0246
dc.subjectepilepsy
dc.subjectneuropeptide Y
dc.subjectpresynaptic inhibition
dc.subjectY2 knockout mouse
dc.subjectY5 receptors
dc.titleThe anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y2 and not Y5 receptorsen
dc.typeArticle

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Department of Psychology