β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish
| dc.contributor.author | Scatterty, Kale R. | |
| dc.contributor.author | Hamilton, Trevor | |
| dc.date.accessioned | 2025-02-05T21:09:26Z | |
| dc.date.available | 2025-02-05T21:09:26Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | The β-Carboline FG-7142 is a partial inverse agonist at the benzodiazepine allosteric site on the GABA-A receptor that induces anxiogenic, proconvulsant, and appetite-reducing effects in many species, including humans. Seizure-kindling effects have been well studied, however anxiogenic properties are relatively unexplored. This study aimed to investigate concentration-dependent effects of FG-7142 on anxiety-like behaviour and fear responses in zebrafish (Danio rerio) using the open-field test (OF) and novel object approach test (NOA). A U-shaped distribution was found with maximal responses in increased immobility and reduced distance moved at 10 µM in the NOA but not the OF. Follow up experiments demonstrated a lack of effect in repeated OF testing and no changes in opercular movements. Furthermore, the effect of FG-7142 was reversed with ethanol treatment. These results suggest that FG-7142 elicits a ‘freezing’ response in zebrafish via the introduction of novelty, suggesting fear-induction. These findings indicate that FG-7142 may act as an agent to promote acute fear responses in zebrafish. | |
| dc.identifier.citation | Scatterty, K. R., & Hamilton, T. J. (2024). β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish. Scientific Reports, 14: 668. https://doi.org/10.1038/s41598-023-51072-6 | |
| dc.identifier.doi | https://doi.org/10.1038/s41598-023-51072-6 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14078/3789 | |
| dc.language.iso | en | |
| dc.rights | Attribution (CC BY) | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | anxiety | |
| dc.subject | fear | |
| dc.subject | FG-7142 | |
| dc.subject | inverse agonists | |
| dc.title | β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish | en |
| dc.type | Article |
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