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A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model

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dc.contributor.authorRezania, Vahid
dc.contributor.authorMarsh, Rebeccah
dc.contributor.authorCoombe, Dennis
dc.contributor.authorTuszynski, Jack A.
dc.date.accessioned2014-10-15
dc.date.accessioned2022-05-27T01:13:19Z
dc.date.available2022-05-27T01:13:19Z
dc.date.issued2013
dc.description.abstractWe develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We have compared drug concentration levels observed exiting the lobule with their predicted detailed distribution inside the lobule, assuming that most often the former is accessible information while the latter is not.
dc.format.extent1.59 mb
dc.format.mimetypePDF
dc.identifier.citationRezania, V., Marsh, R., Coombe, D., & Tuszynski, J. (2013a). A physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule model. Theoretical Biology & Medical Modelling, 10(1), 52. doi:10.1186/1742-4682-10-52
dc.identifier.doihttps://doi.org/10.1186/1742-4682-10-52
dc.identifier.urihttps://hdl.handle.net/20.500.14078/180
dc.languageEnglish
dc.language.isoen
dc.rightsAttribution (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectdrugs
dc.subjectlattice models
dc.titleA physiologically-based flow network model for hepatic drug elimination I: regular lattice lobule modelen
dc.typeArticle
dspace.entity.type

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