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Flexible electrochemical aptasensor for cortisol detection in human sweat

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dc.contributor.authorMugo, Samuel
dc.contributor.authorAlberkant, Jonathan
dc.contributor.authorBernstein, Nina
dc.contributor.authorZenkina, Olena V.
dc.date.accessioned2022-07-25
dc.date.accessioned2022-10-12T21:20:31Z
dc.date.available2022-10-12T21:20:31Z
dc.date.issued2021
dc.description.abstractThis communication demonstrates an electrochemical DNA aptasensor for the detection of cortisol in human sweat. The aptasensor was fabricated via layer-by-layer assembly on stretchable polydimethylsiloxane (PDMS) coated with conductive nanoporous carbon nanotube-cellulose nanocrystals (CNC/CNT) film using a linker to a cortisol specific DNA aptamer. The flexible cortisol aptasensor had a dynamic range of 2.5–35 ng mL−1. The aptasensor precision was determined to be 2.7% relative standard deviation (%RSD) across the concentration dynamic range. The aptasensor was determined to have a limit of detection (LOD) of ∼ 1.8 ng mL−1. The aptasensor was demonstrated to have high selectivity to cortisol and was unresponsive to interfering species including glucose, sodium lactate, and β-estradiol. The aptasensor was successfully evaluated for the detection of cortisol in human sweat indicative of its high specificity.
dc.description.urihttps://library.macewan.ca/cgi-bin/SFX/url.pl/CSM
dc.identifier.citationMugo, S. M., Alberkant, J., Bernstein, N., & Zenkina, O. V. (2021). Flexible electrochemical aptasensor for cortisol detection in human sweat. Analytical Methods 13, 4169-4173. https://doi.org/10.1039/d1ay01233a
dc.identifier.doihttps://doi.org/10.1039/d1ay01233a
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2776
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectaptasensors
dc.subjectcortisol
dc.titleFlexible electrochemical aptasensor for cortisol detection in human sweaten
dc.typeArticle

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