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Wearable microneedle dual electrochemical sensor forsimultaneous pH and cortisol detection in sweat

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dc.contributor.authorMugo, Samuel
dc.contributor.authorLu, Weihao
dc.contributor.authorWood, Marika
dc.contributor.authorLemieux, Stephane
dc.date.accessioned2021-12-21
dc.date.accessioned2022-05-31T01:44:57Z
dc.date.available2022-05-31T01:44:57Z
dc.date.issued2021
dc.description.abstractWe report herewith an inexpensive flexible dual target electrochemical sensor for simultaneous detection of pH and cortisol in human sweat. The sensor was fabricated by printing layer by layer (LbL) on a conductive microneedle polydimethylsiloxane (PDMS) flexible substrate. The dual sensor integrates two detection chambers comprising polyaniline (PANi) and cortisol imprinted poly (glycidylmethacrylate-co ethylene glycol dimethacrylate) (poly (GMA-co-EGDMA)). The dual wearable sensor rapidly (< 1 min) responded linearly to pH in the range of 3–9, while the cortisol sensor chamber had a linear range of 0–100 ng/mL. The cortisol sensing region had an excellent limit of detection (LOD) of 1.4 ± 0.3 ng/mL, with intra-batch reproducibility of 2.4% relative standard deviation (%RSD). The inter-batch precision (%RSD for three different sensors) was determined to be 4.7%. Demonstrating excellent stability and reusability, a single patch of cortisol sensor was used for 15 times over a 30-day period, with minimal change in response. The dual analyte wearable sensors were effective for detection of pH and cortisol in real human sweat.
dc.format.extent2.48MB
dc.format.mimetypePDF
dc.identifier.citationMugo, S. M., Lu, W., Wood, M., Lemieux, S. (2021). Wearable microneedle dual electrochemical sensor forsimultaneous pH and cortisol detection in sweat. Electrochemical Science Advances, e2100039. https://doi.org/10.1002/elsa.202100039
dc.identifier.doihttps://doi.org/10.1002/elsa.202100039
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2523
dc.languageEnglish
dc.language.isoen
dc.rightsAttribution (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcapacitive sweat sensors
dc.subjectdual electrochemical sensor for simultaneous pH and cortisol detection
dc.subjectmicroneedle biomimetic flexible e-skin sensors
dc.subjectPANi-based pH sensors
dc.subjectpoly (GMA-co- EDMA) cortisol imprinted polymer film
dc.titleWearable microneedle dual electrochemical sensor forsimultaneous pH and cortisol detection in sweaten
dc.typeArticle
dspace.entity.type

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