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Flexible molecularly imprinted electrochemical sensor for cortisol monitoring in sweat

dc.contributor.authorMugo, Samuel
dc.contributor.authorAlberkant, Jonathan
dc.date.accessioned2021-07-13
dc.date.accessioned2022-05-31T01:44:14Z
dc.date.available2022-05-31T01:44:14Z
dc.date.issued2020
dc.description.abstractA selective cortisol sensor based on molecularly imprinted poly(glycidylmethacrylate-co ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) has been demonstrated for detection of cortisol in human sweat. The non-enzymatic biomimetric flexible sweat sensor was fabricated inexpensively by layer by layer (LbL) assembly. The sensor layers comprised a stretchable polydimethylsiloxane (PDMS) base with carbon nanotubes-cellulose nanocrystals (CNC/CNT) conductive nanoporous nanofilms. The imprinted (MIP) poly(GMA-co-EGDMA) deposited on the CNC/CNT was the cortisol biomimetric receptor. Rapid in analyte response (3 min), the cortisol MIP sensor demonstrated excellent performance. The sensor has a limit of detection (LOD) of 2.0 ng/mL ± 0.4 ng/mL, dynamic range of 10–66 ng/mL, and a sensor reproducibility of 2.6% relative standard deviation (RSD). The MIP sensor also had high cortisol specificity and was inherently blind to selected interfering species including glucose, epinephrine, β-estradiol, and methoxyprogestrone. The MIP was four orders of magnitude more sensitive than its non-imprinted (NIP) counterpart. The MIP sensor remains stable over time, responding proportionately to doses of cortisol in human sweat.
dc.description.urihttps://library.macewan.ca/cgi-bin/SFX/url.pl/CAC
dc.identifier.citationJ. Alberkant and S. M. Mugo. Flexible molecularly imprinted electrochemical sensor for cortisol monitoring in sweat. Analytical Bioanalytical Chemistry 2020, 316, 1825-1833. DOI: 10.1007/s00216-020-02430-0
dc.identifier.doihttps://doi.org/10.1007/s00216-020-02430-0
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2406
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectbiomimetric flexible sensors
dc.subjectcapacitive sweat sensors
dc.subjectpoly(GMA-co-EGDMA) cortisol imprinted polymer film
dc.titleFlexible molecularly imprinted electrochemical sensor for cortisol monitoring in sweaten
dc.typeArticle

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