Flexible molecularly imprinted electrochemical sensor for cortisol monitoring in sweat
dc.contributor.author | Mugo, Samuel | |
dc.contributor.author | Alberkant, Jonathan | |
dc.date.accessioned | 2021-07-13 | |
dc.date.accessioned | 2022-05-31T01:44:14Z | |
dc.date.available | 2022-05-31T01:44:14Z | |
dc.date.issued | 2020 | |
dc.description.abstract | A selective cortisol sensor based on molecularly imprinted poly(glycidylmethacrylate-co ethylene glycol dimethacrylate) (poly(GMA-co-EGDMA)) has been demonstrated for detection of cortisol in human sweat. The non-enzymatic biomimetric flexible sweat sensor was fabricated inexpensively by layer by layer (LbL) assembly. The sensor layers comprised a stretchable polydimethylsiloxane (PDMS) base with carbon nanotubes-cellulose nanocrystals (CNC/CNT) conductive nanoporous nanofilms. The imprinted (MIP) poly(GMA-co-EGDMA) deposited on the CNC/CNT was the cortisol biomimetric receptor. Rapid in analyte response (3 min), the cortisol MIP sensor demonstrated excellent performance. The sensor has a limit of detection (LOD) of 2.0 ng/mL ± 0.4 ng/mL, dynamic range of 10–66 ng/mL, and a sensor reproducibility of 2.6% relative standard deviation (RSD). The MIP sensor also had high cortisol specificity and was inherently blind to selected interfering species including glucose, epinephrine, β-estradiol, and methoxyprogestrone. The MIP was four orders of magnitude more sensitive than its non-imprinted (NIP) counterpart. The MIP sensor remains stable over time, responding proportionately to doses of cortisol in human sweat. | |
dc.description.uri | https://library.macewan.ca/cgi-bin/SFX/url.pl/CAC | |
dc.identifier.citation | J. Alberkant and S. M. Mugo. Flexible molecularly imprinted electrochemical sensor for cortisol monitoring in sweat. Analytical Bioanalytical Chemistry 2020, 316, 1825-1833. DOI: 10.1007/s00216-020-02430-0 | |
dc.identifier.doi | https://doi.org/10.1007/s00216-020-02430-0 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14078/2406 | |
dc.language | English | |
dc.language.iso | en | |
dc.rights | All Rights Reserved | |
dc.subject | biomimetric flexible sensors | |
dc.subject | capacitive sweat sensors | |
dc.subject | poly(GMA-co-EGDMA) cortisol imprinted polymer film | |
dc.title | Flexible molecularly imprinted electrochemical sensor for cortisol monitoring in sweat | en |
dc.type | Article |