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Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum

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dc.contributor.authorYe, Mengsha
dc.contributor.authorJiang, Mingdi
dc.contributor.authorCheng, Jing
dc.contributor.authorLi, Xuanying
dc.contributor.authorLiu, Ziwei
dc.contributor.authorZhang, Weiying
dc.contributor.authorMugo, Samuel
dc.contributor.authorJaffrezic-Renault, Nicole
dc.contributor.authorGuo, Zhenzhong
dc.date.accessioned2021-07-13
dc.date.accessioned2022-05-31T01:44:14Z
dc.date.available2022-05-31T01:44:14Z
dc.date.issued2020
dc.description.abstractThis study presents a novel electrochemical sensor for detection of Tau-441, an Alzheimer's disease (AD) biomarker protein. The sensor comprised a glassy carbon electrode modified by chemically exfoliated single-layer reduced graphene oxide (rGO) grafted with anti-Tau antibody. Using square wave voltammetry (SWV), the electrochemical sensor yielded a linear response to Tau-441 in the 0.08 pM-80 pM concentration range, with a low detection limit of 75 fM. The sensor has been successfully tested in the detection of Tau-441 of human serum from participants with and without AD, therefore it is shown to be an efficient and effective tool for the early diagnosis of AD.
dc.description.urihttps://library.macewan.ca/cgi-bin/SFX/url.pl/CA7
dc.identifier.citationM. Ye, M. Jiang, J. Cheng, X. Li; Z. Liu, W. Zhang, S.M. Mugo, N. Jaffrezic-Renault ; Z. Guo. Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum. Sensors and Actuators B: Chemical. 2020, 308, 127692. DOI: 10.1016/j.snb.2020.127692
dc.identifier.doihttps://doi.org/10.1016/j.snb.2020.127692
dc.identifier.urihttps://hdl.handle.net/20.500.14078/2405
dc.languageEnglish
dc.language.isoen
dc.rightsAll Rights Reserved
dc.subjectAlzheimer's disease
dc.subjectTau-441
dc.subjectelectrochemical antibody sensor
dc.subjectsingle layer reduced graphene oxide (rGO)
dc.subject1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt
dc.subject(PTSA)
dc.titleSingle-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serumen
dc.typeArticle

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