Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum
dc.contributor.author | Ye, Mengsha | |
dc.contributor.author | Jiang, Mingdi | |
dc.contributor.author | Cheng, Jing | |
dc.contributor.author | Li, Xuanying | |
dc.contributor.author | Liu, Ziwei | |
dc.contributor.author | Zhang, Weiying | |
dc.contributor.author | Mugo, Samuel | |
dc.contributor.author | Jaffrezic-Renault, Nicole | |
dc.contributor.author | Guo, Zhenzhong | |
dc.date.accessioned | 2021-07-13 | |
dc.date.accessioned | 2022-05-31T01:44:14Z | |
dc.date.available | 2022-05-31T01:44:14Z | |
dc.date.issued | 2020 | |
dc.description.abstract | This study presents a novel electrochemical sensor for detection of Tau-441, an Alzheimer's disease (AD) biomarker protein. The sensor comprised a glassy carbon electrode modified by chemically exfoliated single-layer reduced graphene oxide (rGO) grafted with anti-Tau antibody. Using square wave voltammetry (SWV), the electrochemical sensor yielded a linear response to Tau-441 in the 0.08 pM-80 pM concentration range, with a low detection limit of 75 fM. The sensor has been successfully tested in the detection of Tau-441 of human serum from participants with and without AD, therefore it is shown to be an efficient and effective tool for the early diagnosis of AD. | |
dc.description.uri | https://library.macewan.ca/cgi-bin/SFX/url.pl/CA7 | |
dc.identifier.citation | M. Ye, M. Jiang, J. Cheng, X. Li; Z. Liu, W. Zhang, S.M. Mugo, N. Jaffrezic-Renault ; Z. Guo. Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum. Sensors and Actuators B: Chemical. 2020, 308, 127692. DOI: 10.1016/j.snb.2020.127692 | |
dc.identifier.doi | https://doi.org/10.1016/j.snb.2020.127692 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14078/2405 | |
dc.language | English | |
dc.language.iso | en | |
dc.rights | All Rights Reserved | |
dc.subject | Alzheimer's disease | |
dc.subject | Tau-441 | |
dc.subject | electrochemical antibody sensor | |
dc.subject | single layer reduced graphene oxide (rGO) | |
dc.subject | 1,3,6,8-pyrenetetrasulfonic acid tetrasodium salt | |
dc.subject | (PTSA) | |
dc.title | Single-layer exfoliated reduced graphene oxide-antibody Tau sensor for detection in human serum | en |
dc.type | Article |